Deskripsi Pekerjaan
Are you ready to pioneer the next generation of RNA therapeutics? The Agency for Science, Technology and Research (A*STAR) in Singapore is seeking a highly motivated and innovative Scientist to join our world-class team focused on Bioconjugation & Targeted RNA Delivery.
This is a unique and exciting opportunity to drive breakthroughs in drug development. You will leverage cutting-edge chemical biology and nanomedicine platforms to design novel bioconjugation strategies and develop advanced delivery vehicles, unlocking the full therapeutic potential of RNA. RNA therapies represent the next frontier in treating a vast range of genetic, infectious, and oncological diseases. Our team is at the absolute forefront of designing intelligent delivery systems that can precisely overcome biological barriers to reach target cells with high efficiency.
As a key member of our interdisciplinary team, you will spearhead projects from concept through preclinical validation. You will have the unique opportunity to work on a diverse pipeline of mRNA, siRNA, and saRNA candidates and will utilize high-throughput screening, state-of-the-art analytical techniques, and advanced characterization tools. You will design novel strategies to conjugate targeting ligands, optimize pharmacokinetic profiles, and minimize off-target effects. A*STAR offers a vibrant, supportive environment with access to elite core facilities and a strong commitment to translating scientific discoveries into real-world impacts.
You will work collaboratively with leading international researchers and industry partners to develop robust and scalable platforms. Singapore's dynamic and rapidly growing biomedical research ecosystem provides the perfect backdrop for this groundbreaking work. If you are passionate about RNA biology, chemistry, and drug delivery, and want to make a tangible difference in global health, we want to hear from you.
Tanggung Jawab
- Design and synthesize novel bioconjugates (lipids, polymers, peptides) for targeted RNA delivery to specific cells and tissues.
- Lead the development and optimization of lipid nanoparticle (LNP) formulations to enhance stability, potency, and biocompatibility.
- Physiochemically characterize delivery systems using techniques such as DLS, NTA, HPLC, and cryo-EM.
- Conduct comprehensive in vitro and in vivo studies to evaluate targeting efficiency, biodistribution, and therapeutic efficacy.
- Develop and validate robust analytical methods for the quantification of RNA payloads and their conjugates.
- Collaborate with multidisciplinary teams across biology, pharmacology, and DMPK to advance drug candidates.
- Maintain meticulous experimental records, prepare technical reports, and present findings at internal and international conferences.
- Contribute to grant writing, patent filings, and high-impact scientific publications.
Kualifikasi
- PhD in Chemistry, Chemical Biology, Biochemistry, Pharmaceutical Sciences, or a closely related field.
- Minimum 2-4 years of postdoctoral or industry experience in bioconjugation, nucleic acid chemistry, or drug delivery.
- Strong hands-on expertise in organic synthesis, bioconjugation techniques, and purification methods (e.g., HPLC, FPLC).
- In-depth understanding of RNA biology, pharmacology, and the challenges of intracellular delivery.
- Significant experience with lipid nanoparticle (LNP) formulation, characterization, and optimization is highly preferred.
- Excellent problem-solving skills and a demonstrated ability to drive complex research projects independently.
- Proven publication record in high-quality, peer-reviewed international journals.
- Outstanding verbal and written communication skills in English. Ability to thrive in a collaborative, fast-paced environment.